Originally published June 06, 2019 · Adapted October 27, 2026
Growth factors are signaling proteins involved in processes such as cell activity and tissue repair. Platelets contain proteins that are part of the body’s response to injury. This biology helps explain the interest in platelet-rich plasma.
What PRP changes
PRP preparation concentrates platelets from a blood sample. Preparations can differ. Ask what the proposed preparation contains, how it is produced, and why that approach is being considered for the condition being treated.
Biology is the beginning of the question
A mechanism that makes sense in a laboratory does not establish how much pain relief or functional improvement a patient should expect. Clinical research needs to examine the specific condition, preparation, comparison treatment, and outcomes that matter to patients.
Ask about meaningful outcomes
For you, progress may mean tolerating stairs, walking farther, returning to a particular activity, or needing less interruption during a workday. Ask how those goals would be measured and when the plan would be reviewed.
Keep the whole plan in view
Discuss rehabilitation, other care options, risks, costs, and follow-up. More concentrated material or a higher number of injections should not be treated as an automatic promise of a better result. The decision should fit the diagnosis and the available evidence.
Connect the information to your care.
Explore PRP consultations → · Second opinions →
Discuss your next step ↗Patient information: AAOS PRP patient guide ↗. Evidence and suitability depend on the individual condition.